Barbara McClintock (June 16, 1902 – September 2, 1992)

Barbara McClintock (June 16, 1902 – September 2, 1992), was an American scientist and one of the world's most distinguished cytogeneticists, the 1983 Nobel laureate in Physiology or Medicine. McClintock received her PhD in botany from Cornell University in 1927. There she started her career as the leader in the development of maize cytogenetics, the focus of her research for the rest of her life. From the late 1920s, McClintock studied chromosomes and how they change during reproduction in maize. Her work was groundbreaking; she developed the technique for visualizing maize chromosomes and used microscopic analysis to demonstrate many fundamental genetic ideas. One of those ideas was the notion of genetic recombination by crossing-over during meiosis—a mechanism by which chromosomes exchange information. She produced the first genetic map for maize, linking regions of the chromosome to physical traits. She demonstrated the role of the telomere and centromere, regions of the chromosome that are important in the conservation of genetic information. She was recognized among the best in the field, awarded prestigious fellowships, and elected a member of the National Academy of Sciences in 1944.

During the 1940s and 1950s, McClintock discovered transposition and used it to demonstrate that genes are responsible for turning physical characteristics on and off. She developed theories to explain the suppression and expression of genetic information from one generation of maize plants to the next. Due to skepticism of her research and its implications, she stopped publishing her data in 1953.

Later, she made an extensive study of the cytogenetics and ethnobotany of maize races from South America. McClintock's research became well understood in the 1960s and 1970s, as other scientists confirmed the mechanisms of genetic change and genetic regulation that she had demonstrated in her maize research in the 1940s and 1950s. Awards and recognition for her contributions to the field followed, including the Nobel Prize for Physiology or Medicine, awarded to her in 1983 for the discovery of genetic transposition; she is the only woman to receive an unshared Nobel Prize in that category.

Barbara McClintock was born Eleanor McClintock on June 16, 1902 in Hartford, Connecticut, the third of four children born to physician Thomas Henry McClintock and Sara Handy McClintock. Thomas McClintock was the child of British immigrants, and Sara Handy, born Grace, descended from an old American Mayflower family. Marjorie, the oldest child, was born in October 1898; Mignon, the second daughter, was born in November 1900. The youngest, Malcolm Rider (called Tom), was born 18 months after Barbara. As a young girl, her parents determined that Eleanor, a "feminine" and "delicate" name, was not appropriate for her, and chose Barbara instead. McClintock was an independent child beginning at a very young age, a trait she later identified as her "capacity to be alone". From the age of three until she began school, McClintock lived with an aunt and uncle in Brooklyn, New York in order to reduce the financial burden on her parents while her father established his medical practice. She was described as a solitary and independent child, and a tomboy. She was close to her father, but had a difficult relationship with her mother, tension that began when she was young.

The McClintock family moved to Brooklyn in 1908 and McClintock completed her secondary education there at Erasmus Hall High School; she graduated early in 1919. She discovered her love of science and reaffirmed her solitary personality during high school. She wanted to continue her studies at Cornell University's College of Agriculture. Her mother resisted sending McClintock to college, for fear that she would be unmarriageable. McClintock was almost prevented from starting college, but her father intervened just before registration began, and she matriculated at Cornell in 1919.

McClintock began her studies at Cornell's College of Agriculture in 1919. There, she participated in student government and was invited to join a sorority, though she soon realized that she preferred not to join formal organizations. Instead, McClintock took up music, specifically jazz. She studied botany, receiving a BSc in 1923. Her interest in genetics began when she took her first course in that field in 1921. The course was based on a similar one offered at Harvard University, and was taught by C. B. Hutchison, a plant breeder and geneticist. Hutchison was impressed by McClintock's interest, and telephoned to invite her to participate in the graduate genetics course at Cornell in 1922. McClintock pointed to Hutchison's invitation as the reason she continued in genetics: "Obviously, this telephone call cast the die for my future. I remained with genetics thereafter." Although it has been reported that women could not major in genetics at Cornell, and therefore her MA and PhD—earned in 1925 and 1927, respectively—were officially awarded in botany, recent research has revealed that women did earn graduate degrees in Cornell's Plant Breeding Department during the time that McClintock was a student at Cornell.

During her graduate studies and postgraduate appointment as a botany instructor, McClintock was instrumental in assembling a group that studied the new field of cytogenetics in maize. This group brought together plant breeders and cytologists, and included Marcus Rhoades, future Nobel laureate George Beadle, and Harriet Creighton. Rollins A. Emerson, head of the Plant Breeding Department, supported these efforts, although he was not a cytologist himself.

McClintock's cytogenetic research focused on developing ways to visualize and characterize maize chromosomes. This particular part of her work influenced a generation of students, as it was included in most textbooks. She also developed a technique using carmine staining to visualize maize chromosomes, and showed for the first time the morphology of the 10 maize chromosomes. This discovery was made because she observed cells from the microspore as opposed to the root tip. By studying the morphology of the chromosomes, McClintock was able to link specific chromosome groups of traits that were inherited together. Marcus Rhoades noted that McClintock's 1929 Genetics paper on the characterization of triploid maize chromosomes triggered scientific interest in maize cytogenetics, and attributed to her 10 of the 17 significant advances in the field that were made by Cornell scientists between 1929 and 1935.

In 1930, McClintock was the first person to describe the cross-shaped interaction of homologous chromosomes during meiosis. The following year, McClintock and Creighton proved the link between chromosomal crossover during meiosis and the recombination of genetic traits. They observed how the recombination of chromosomes seen under a microscope correlated with new traits. Until this point, it had only been hypothesized that genetic recombination could occur during meiosis, although it had been shown genetically. McClintock published the first genetic map for maize in 1931, showing the order of three genes on maize chromosome 9. This information provided necessary data for the crossing-over study she published with Creighton; they also showed that crossing-over occurs in sister chromatids as well as homologous chromosomes. In 1938, she produced a cytogenetic analysis of the centromere, describing the organization and function of the centromere, as well as the fact that it can divide.

McClintock's breakthrough publications, and support from her colleagues, led to her being awarded several postdoctoral fellowships from the National Research Council. This funding allowed her to continue to study genetics at Cornell, the University of Missouri, and the California Institute of Technology, where she worked with E. G. Anderson. During the summers of 1931 and 1932, she worked at Missouri with geneticist Lewis Stadler, who introduced her to the use of X-rays as a mutagen. Exposure to X-rays can increase the rate of mutation above the natural background level, making it a powerful research tool for genetics. Through her work with X-ray-mutagenized maize, she identified ring chromosomes, which form when the ends of a single chromosome fuse together after radiation damage. From this evidence, McClintock hypothesized that there must be a structure on the chromosome tip that would normally ensure stability. She showed that the loss of ring-chromosomes at meiosis caused variegation in maize foliage in generations subsequent to irradiation resulting from chromosomal deletion. During this period, she demonstrated the presence of the nucleolus organizer region on a region on maize chromosome 6, which is required for the assembly of the nucleolus. In 1933, she established that cells can be damaged when nonhomologous recombination occurs. During this same period, McClintock hypothesized that the tips of chromosomes are protected by telomeres.

McClintock received a fellowship from the Guggenheim Foundation that made possible six months of training in Germany during 1933 and 1934. She had planned to work with Curt Stern, who had demonstrated crossing-over in Drosophila just weeks after McClintock and Creighton had done so; however, Stern emigrated to the United States. Instead, she worked with geneticist Richard B. Goldschmidt, who was the head of the Kaiser Wilhelm Institute. She left Germany early amidst mounting political tension in Europe, and returned to Cornell, remaining there until 1936, when she accepted an Assistant Professorship offered to her by Lewis Stadler in the Department of Botany at the University of Missouri-Columbia. While still at Cornell, she was supported by a two-year Rockefeller Foundation grant obtained for her through Emerson's efforts.

During her time at Missouri, McClintock expanded her research on the effect of X-rays on maize cytogenetics. McClintock observed the breakage and fusion of chromosomes in irradiated maize cells. She was also able to show that, in some plants, spontaneous chromosome breakage occurred in the cells of the endosperm. Over the course of mitosis, she observed that the ends of broken chromatids were rejoined after the chromosome replication. In the anaphase of mitosis, the broken chromosomes formed a chromatid bridge, which was broken when the chromatids moved towards the cell poles. The broken ends were rejoined in the interphase of the next mitosis, and the cycle was repeated, causing massive mutation, which she could detect as variegation in the endosperm. This breakage–rejoining–bridge cycle was a key cytogenetic discovery for several reasons. First, it showed that the rejoining of chromosomes was not a random event, and second, it demonstrated a source of large-scale mutation. For this reason, it remains an area of interest in cancer research today.

Although her research was progressing at Missouri, McClintock was not satisfied with her position at the University. She recalled being excluded from faculty meetings, and was not made aware of positions available at other institutions. In 1940, she wrote to Charles Burnham, "I have decided that I must look for another job. As far as I can make out, there is nothing more for me here. I am an assistant professor at $3,000 and I feel sure that that is the limit for me." Initially, McClintock's position was created especially for her by Stadler, and might have depended on his presence at the university. McClintock believed she would not gain tenure at Missouri, even though according to some accounts, she knew she would be offered a promotion from Missouri in the spring of 1942. Recent evidence reveals that McClintock more likely decided to leave Missouri because she had lost trust in her employer and in the University administration, after discovering that her job would be in jeopardy if Stadler were to leave for Caltech, as he had considered doing. The university's retaliation against Stadler amplified her sentiments.

In early 1941, she took a leave of absence from Missouri in hopes of finding a position elsewhere. She accepted a visiting Professorship at Columbia University, where her former Cornell colleague Marcus Rhoades was a professor. Rhoades also offered to share his research field at Cold Spring Harbor on Long Island. In December 1941, she was offered a research position by Milislav Demerec, the newly appointed acting director of the Carnegie Institution of Washington's Department of Genetics Cold Spring Harbor Laboratory; McClintock accepted his invitation despite her qualms and became a permanent member of the faculty.

After her year-long temporary appointment, McClintock accepted a full-time research position at Cold Spring Harbor Laboratory. There, she was highly productive and continued her work with the breakage-fusion-bridge cycle, using it to substitute for X-rays as a tool for mapping new genes. In 1944, in recognition of her prominence in the field of genetics during this period, McClintock was elected to the National Academy of Sciences—only the third woman to be elected. That same year, she became the first female president of the Genetics Society of America; she was elected its vice-president in 1939. In 1944 she undertook a cytogenetic analysis of Neurospora crassa at the suggestion of George Beadle, who used the fungus to demonstrate the one gene–one enzyme relationship. He invited her to Stanford to undertake the study. She successfully described the number of chromosomes, or karyotype, of N. crassa and described the entire life cycle of the species. N. crassa has since become a model species for classical genetic analysis.

The relationship of Ac/Ds in the control of the elements and mosaic color of maize. The seed in 10 is colorless, there is no Ac element present and Ds inhibits the synthesis of colored pigments called anthocyanins. In 11 to 13, one copy of Ac is present. Ds can move and some anthocyanin is produced, creating a mosaic pattern. In the kernel in panel 14 there are two Ac elements and in 15 there are three.

In the summer of 1944 at Cold Spring Harbor Laboratory, McClintock began systematic studies on the mechanisms of the mosaic color patterns of maize seed and the unstable inheritance of this mosaicism. She identified two new dominant and interacting genetic loci that she named Dissociator (Ds) and Activator (Ac). She found that the Dissociator did not just dissociate or cause the chromosome to break, it also had a variety of effects on neighboring genes when the Activator was also present, which included making certain stable mutations unstable. In early 1948, she made the surprising discovery that both Dissociator and Activator could transpose, or change position, on the chromosome.

She observed the effects of the transposition of Ac and Ds by the changing patterns of coloration in maize kernels over generations of controlled crosses, and described the relationship between the two loci through intricate microscopic analysis. She concluded that Ac controls the transposition of the Ds from chromosome 9, and that the movement of Ds is accompanied by the breakage of the chromosome. When Ds moves, the aleurone-color gene is released from the suppressing effect of the Ds and transformed into the active form, which initiates the pigment synthesis in cells. The transposition of Ds in different cells is random, it may move in some but not others, which causes color mosaicism. The size of the colored spot on the seed is determined by stage of the seed development during dissociation. McClintock also found that the transposition of Ds is determined by the number of Ac copies in the cell.

Between 1948 and 1950, she developed a theory by which these mobile elements regulated the genes by inhibiting or modulating their action. She referred to Dissociator and Activator as "controlling units"—later, as "controlling elements"—to distinguish them from genes. She hypothesized that gene regulation could explain how complex multicellular organisms made of cells with identical genomes have cells of different function. McClintock's discovery challenged the concept of the genome as a static set of instructions passed between generations. In 1950, she reported her work on Ac/Ds and her ideas about gene regulation in a paper entitled "The origin and behavior of mutable loci in maize" published in the journal Proceedings of the National Academy of Sciences. In summer 1951, when she reported her work on the origin and behavior of mutable loci in maize at the annual symposium at Cold Spring Harbor Laboratory, presenting a paper of the same name. The paper delved into the instability caused by Dc and As or just As in four genes, along with the tendency of those genes to unpredictably revert to the wild phenotype. She also identified "families" of transposons, which did not interact with one another.

Her work on controlling elements and gene regulation was conceptually difficult and was not immediately understood or accepted by her contemporaries; she described the reception of her research as "puzzlement, even hostility". Nevertheless, McClintock continued to develop her ideas on controlling elements. She published a paper in Genetics in 1953, where she presented all her statistical data, and undertook lecture tours to universities throughout the 1950s to speak about her work. She continued to investigate the problem and identified a new element that she called Suppressor-mutator (Spm), which, although similar to Ac/Ds, acts in a more complex manner. Like Ac/Ds, some versions could transpose on their own and some could not; unlike Ac/Ds, when present, it fully suppressed the expression of mutant genes when they normally would not be entirely suppressed. Based on the reactions of other scientists to her work, McClintock felt she risked alienating the scientific mainstream, and from 1953 stopped publishing accounts of her research on controlling elements.

McClintock's microscope and ears of corn on exhibition at the National Museum of Natural History
In 1957, McClintock received funding from the National Academy of Sciences to start research on indigenous strains of maize in Central America and South America. She was interested in studying the evolution of maize through chromosomal changes, and being in South America would allow her to work on a larger scale. McClintock explored the chromosomal, morphological, and evolutionary characteristics of various races of maize. After extensive work in the 1960s and 1970s, McClintock and her collaborators published the seminal study The Chromosomal Constitution of Races of Maize, leaving their mark on paleobotany, ethnobotany, and evolutionary biology.

McClintock officially retired from her position at the Carnegie Institution in 1967, and was made a Distinguished Service Member of the Carnegie Institution of Washington. This honor allowed her to continue working with graduate students and colleagues in the Cold Spring Harbor Laboratory as scientist emerita; she lived in the town. In reference to her decision 20 years earlier to stop publishing detailed accounts of her work on controlling elements, she wrote in 1973:

"Over the years I have found that it is difficult if not impossible to bring to consciousness of another person the nature of his tacit assumptions when, by some special experiences, I have been made aware of them. This became painfully evident to me in my attempts during the 1950s to convince geneticists that the action of genes had to be and was controlled. It is now equally painful to recognize the fixity of assumptions that many persons hold on the nature of controlling elements in maize and the manners of their operation. One must await the right time for conceptual change."

The importance of McClintock's contributions was revealed in the 1960s, when the work of French geneticists Francois Jacob and Jacques Monod described the genetic regulation of the lac operon, a concept she had demonstrated with Ac/Ds in 1951. Following Jacob and Monod's 1961 Journal of Molecular Biology paper "Genetic regulatory mechanisms in the synthesis of proteins", McClintock wrote an article for American Naturalist comparing the lac operon and her work on controlling elements in maize. McClintock's contribution to biology is still not widely acknowledged as amounting to the discovery of genetic regulation.

McClintock was widely credited for discovering transposition after other researchers finally discovered the process in bacteria, yeast, and bacteriophages in the late 1960s and early 1970s. During this period, molecular biology had developed significant new technology, and scientists were able to show the molecular basis for transposition. In the 1970s, Ac and Ds were cloned by other scientists and were shown to be Class II transposons. Ac is a complete transposon that can produce a functional transposase, which is required for the element to move within the genome. Ds has a mutation in its transposase gene, which means that it cannot move without another source of transposase. Thus, as McClintock observed, Ds cannot move in the absence of Ac. Spm has also been characterized as a transposon. Subsequent research has shown that transposons typically do not move unless the cell is placed under stress, such as by irradiation or the breakage-fusion-bridge cycle, and thus their activation during stress can serve as a source of genetic variation for evolution. McClintock understood the role of transposons in evolution and genome change well before other researchers grasped the concept. Nowadays, Ac/Ds is used as a tool in plant biology to generate mutant plants used for the characterization of gene function.

In 1947, McClintock received the Achievement Award from the American Association of University Women. She was elected a Fellow of the American Academy of Arts and Sciences in 1959. In 1967, McClintock was awarded the Kimber Genetics Award; three years later, she was given the National Medal of Science by Richard Nixon in 1970. Cold Spring Harbor named a building in her honor in 1973. She received the Louis and Bert Freedman Foundation Award and the Lewis S. Rosensteil Award in 1978. In 1981, she became the first recipient of the MacArthur Foundation Grant, and was awarded the Albert Lasker Award for Basic Medical Research, the Wolf Prize in Medicine and the Thomas Hunt Morgan Medal by the Genetics Society of America. In 1982, she was awarded the Louisa Gross Horwitz Prize from Columbia University for her research in the "evolution of genetic information and the control of its expression."

Most notably, she received the Nobel Prize for Physiology or Medicine in 1983, the first woman to win that prize unshared, credited by the Nobel Foundation for discovering "mobile genetic elements"; it was more than 30 years after she initially described the phenomenon of controlling elements. She was compared to Gregor Mendel in terms of her scientific career by the Swedish Academy of Sciences when she was awarded the Prize.

She was elected a Foreign Member of the Royal Society in 1989. McClintock received the Benjamin Franklin Medal for Distinguished Achievement in the Sciences of the American Philosophical Society in 1993. She was awarded 14 Honorary Doctor of Science degrees and an Honorary Doctor of Humane Letters. In 1986 she was inducted into the National Women's Hall of Fame. During her final years, McClintock led a more public life, especially after Evelyn Fox Keller's 1983 biography of her, A Feeling for the Organism, brought McClintock's story to the public. She remained a regular presence in the Cold Spring Harbor community, and gave talks on mobile genetic elements and the history of genetics research for the benefit of junior scientists. An anthology of her 43 publications The Discovery and Characterization of Transposable Elements: The Collected Papers of Barbara McClintock was published in 1987.

Since her death, McClintock has been the subject of the biography by science historian Nathaniel C. Comfort's The Tangled Field: Barbara McClintock's Search for the Patterns of Genetic Control. Comfort's biography contests some claims about McClintock, described as the "McClintock Myth", which he claims was perpetuated by the earlier biography by Keller. Keller's thesis was that McClintock was long ignored or met with derision because she was a woman working in the sciences. For example, when McClintock presented her findings that the genetics of maize did not conform to Mendelian distributions, geneticist Sewall Wright expressed the belief that she did not understand the underlying mathematics of her work, a belief he had expressed towards other women at the time. In addition, geneticist Lotte Auerbach recounted that Joshua Lederberg returned from a visit to McClintock's lab with the remark: 'By God, that woman is either crazy or a genius.' " As Auerbach tells it, McClintock had thrown Lederberg and his colleagues out after half an hour 'because of their arrogance. She was intolerant of arrogance ... She felt she had crossed a desert alone and no one had followed her.'"

Comfort, however, asserts that McClintock was well regarded by her professional peers, even in the early years of her career. Although Comfort argues that McClintock was not a victim of gender discrimination, she has been widely written about in the context of women's studies. Most recent biographical works on women in science feature accounts of her experience. She is held up as a role model for girls in such works of children's literature as Edith Hope Fine's Barbara McClintock, Nobel Prize Geneticist, Deborah Heiligman's Barbara McClintock: Alone in Her Field and Mary Kittredge's Barbara McClintock. A recent biography for young adults by Naomi Pasachoff, Barbara McClintock, Genius of Genetics, provides a new perspective, based on the current literature.

On May 4, 2005, the United States Postal Service issued the "American Scientists" commemorative postage stamp series, a set of four 37-cent self-adhesive stamps in several configurations. The scientists depicted were Barbara McClintock, John von Neumann, Josiah Willard Gibbs, and Richard Feynman. McClintock was also featured in a 1989 four-stamp issue from Sweden which illustrated the work of eight Nobel Prize-winning geneticists. A small building at Cornell University and a laboratory building at Cold Spring Harbor Laboratory were named for her. A street has been named after her in the new "Adlershof Development Society" science park in Berlin.

Some of McClintock's personality and scientific achievements were referred to in Jeffrey Eugenides's 2011 novel The Marriage Plot, which tells the story of a yeast geneticist named Leonard who suffers from bipolar disorder. He works at a laboratory loosely based on Cold Spring Harbor. The character reminiscent of McClintock is a reclusive geneticist at the fictional laboratory, who makes the same discoveries as her factual counterpart.

Marie Maynard Daly (April 16, 1921 – October 28, 2003)

Marie Maynard Daly was an American biochemist. She was the first Caribbean American woman in the United States to earn a Ph.D. in chemistry (awarded by Columbia University in 1947).

Daly's father had immigrated from the British West Indies, found work as a postal clerk, and eventually married Helen Page of Washington, D.C. They lived in New York, and Daly was born and raised in Corona, Queens. She often visited her maternal grandparents in Washington, where she was able to read about scientists and their achievements in her grandfather’s extensive library. She was especially impressed by Paul de Kruif’s The Microbe Hunters, a work which partially influenced her decision to become a scientist.

Daly’s father, who had attended Cornell University with intentions of becoming a chemist, was unable to complete his education due to a lack of funds. His daughter continued her father’s legacy by majoring in chemistry.

After Daly graduated from all-girls Hunter College High School (where she was also encouraged to pursue chemistry), she enrolled in Queens College, a small, fairly new school in Flushing, New York. She lived at a home to save money, majored in chemistry, and graduated from Queens magna cum laude with her bachelor's degree in chemistry in 1942.

Daly remained at Queens College for another year, working as a laboratory assistant while attending graduate school at New York University. She completed her masters in Chemistry in 1 year. She then enrolled in the doctoral program at Columbia University, where she was supervised by Dr. Mary L. Caldwell. Caldwell, who had a doctorate in nutrition, helped Daly discover how chemicals produced in the body contribute to food digestion. Daly completed her Ph.D. in chemistry in 1947. Her dissertation addressed “A Study of the Products Formed by the Action of Pancreatic Amylase on Corn Starch.”

Daly served two years as a physical science instructor at Howard University. After being awarded an American Cancer Society grant to support her postdoctoral research, she joined Dr. A. E. Mirsky at the Rockefeller Institute, where they studied the cell nucleus. In 1953, after Watson and Crick described the structure of DNA, Daly’s world changed significantly: suddenly, the cell nucleus research field was flooded with funding opportunities. Her work flourished in the new environment.

In 1955 Daly returned to Columbia’s College of Physicians and Surgeons to teach biochemistry. She began collaborating with Dr. Quentin B. Deming to investigate the underlying causes of heart attacks. They found that high cholesterol levels contributed to the blockage of arteries that supply oxygen to the heart. She also investigated the effects of sugar on the function of coronary arteries. Later, she became a pioneer in studying the impact of cigarette smoking on the lungs.

In 1960 Daly and Deming moved to Yeshiva University at the Albert Einstein College of Medicine in New York City. At Yeshiva, she continued her research and taught biochemistry courses. She enjoyed teaching medical students and was dedicated to increasing the number of minority students enrolled in medical schools. In 1961 Daly married Vincent Clark.

Daly also served as an investigator for the American Heart Association; she was especially interested in how hypertension affects the circulatory system. She was a member of the prestigious Board of Governors of the New York Academy of Sciences for two years. Daly retired from the Einstein College of Medicine in 1986, and in 1988 she established a scholarship for African American chemistry and physics majors at Queens College in memory of her father.

Janet Emerson Bashen (February 12, 1957- Present)

Janet Emerson Bashen is an American inventor, entrepreneur, and business consultant. She patented a software program to assist with web-based equal employment opportunity investigations. She founded a human resource consulting firm focusing on equal employment opportunity compliance, which investigated civil rights violations and employee misconduct. From 1997 to 2001, according to Inc magazine, her firm's revenue grew 552%, at which time it had 43 employees. In May 2000, she argued before Congress that civil rights and employee misconduct investigations should be exempt from the Fair Credit Reporting Act. In 2012, she was named to Ebony magazine's list of the 100 most influential African-Americans in entertainment, politics, sports and business, called the Power 100 List.

Dr. Giuliana Tesoro (June 1, 1921 – September 29, 2002)

Giuliana Cavaglieri was born in 1921 in Venice into a Jewish family. Her father, Gino Cavaglieri, managed an insurance firm; he died when Giuliana was only twelve. In 1938, after completing her high school education, she was denied access to Italy's university system due to the promulgation of the Fascist Racial Laws. She moved to Switzerland first and then in 1939 to the United States.

In the United States she was allowed to enter Yale University's graduate program and completed it in record time. In 1943, at the age of 21, Cavaglieri received her Ph.D. in Organic Chemistry. The same year she married Victor Tesoro, with whom she would have two children.

Following her marriage, Giuliana Cavaglieri Tesoro worked summers for Calico Chemical Company before accepting a position as research chemist at Onyx Oil and Chemical Company in 1944. Here she was promoted to head of the organic synthesis department in 1946, assistant director of research in 1955, and associate director in 1957. She was then appointed assistant director of organic research for J.P. Stevens & Company. Late she moved to the Textile Research Institute for two years. In 1969, she accepted a position as senior chemist at Burlington Industries and was appointed director of chemical research in 1971.

In 1972 she accepted a post as Visiting Professor at the Massachusetts Institute of Technology, where she taught until 1976, remaining on the Faculty as adjunct professor and senior research scientist until 1982. She was then appointed research professor at Polytechnic Institute of New York University in Brooklyn, New York in 1982 and retired from there in 1996.

Tesoro made a number of advances in textile processing and organic compounds that improved textile performance for everyday consumers as well as efficiency for manufacturing systems. She developed flame-resistant fibers, designed ways to prevent static accumulation in synthetic fibers, and created improved permanent press properties for textiles.

Ruth Wakefield (June 17, 1903 - January 10, 1977)

Wakefield was educated at Framingham State Normal School Department of Household Arts in 1924. Then, she worked as a dietitian and lectured about foods. In 1930, she and her husband Kenneth Donald Wakefield (1897-1997) bought a tourist lodge in the town of Whitman, Massachusetts in Plymouth County. Located about halfway between Boston and New Bedford, it was a place where passengers had historically paid a toll, changed horses and ate home-cooked meals. When the Wakefields opened their business, they named the establishment the Toll House Inn. Ruth cooked and served all the food and soon gained local fame for her desserts. She invented chocolate chip cookies around 1938. The restaurant had many visitors, including Massachusetts' Senator John F. Kennedy. Her chocolate chip cookies soon became very popular.

Wakefield stated that she deliberately invented the cookie. She said, "We had been serving a thin butterscotch nut cookie with ice cream. Everybody seemed to love it, but I was trying to give them something different. So I came up with Toll House cookie."

Wakefield wrote a cookbook, Toll House Tried and True Recipes, that went through 39 printings starting in 1930. The 1938 edition of the cookbook was the first to include the recipe for a chocolate chip cookie, the "Toll House Chocolate Crunch Cookie".

Wakefield gave Nestlé the right to use her cookie recipe and the Toll House name for one dollar. Nestlé began marketing chocolate chips to be used especially for cookies.

Wakefield died following a long illness in Jordan Hospital in Plymouth, Massachusetts.

Rachel Zimmerman (1972 - Present)

Rachel Zimmerman born in Ontario Canada 1972, grew up an inquisitive young girl, with a role model of a mother. Linda Zimmerman was the founder and president of her own software company and gave Rachel inspiration to enter the field of technology. She was a young girl that liked girl scouts and science.

The turning point in her life came when in the sixth grade, while researching Keller and Braille, she stumbled across a book on Blissymbols. With the idea of a science fair coming soon, she dove into everything about the system Blissymbols, communication system for the severely disabled, and decided to research other methods to improve it’s accessibility. It was then, at the science fair at the age of 12, that she created the Blissymbol printer.

This new device used a software program to enable those using Blissymbol language to “talk” to each other and preform all the other types of communication through the computer. Until then the user needed another person to translate the symbols they would point out. With the new printer, she developed a tap pad that enabled the person to simply touch the board and the software would do the translating, transmitting the output in the language of the user’s choice onto a computer screen. When she initially presented the concept at a science fair, it received a silver medal and she went on to compete in the World Exhibition of Achievement of Young Inventors. The Blissymbols printer also ended up winning a silver medal at the Canada-wide contest. Rachel Zimmerman, along with her forward-thinking invention, were showcased when they won a VTV Television Youth Achievement Award. Rachel continues her passion for the sciences.

Today according to her Linkin profile, she attended Bradeis University and International Space University. She has worked for

• Outreach Specialist at NASA Jet Propulsion Laboratory

• Education Outreach Coordinator at Jet Propulsion Laboratory

Past

• Education and Outreach Specialist at California Institute of Technology (Caltech)

• Education and Outreach Coordinator at The Planetary Society

• Space Vision System Specialist at Canadian Space Agency

• Intern at NASA Ames Research Center

• Master of Space Studies student at International Space University

Rachel now works for NASA and still has the same concern for those who are not able-bodied. She is currently helping NASA mold their innovations to better fit the needs of disabled people. To this day she works on better forms of communications for the disabled. Below is and example of a tap=board used by those severely handicapped for communication, thanks to Rachel Zimmerman.

Patricia Era Bath (November 4, 1942 - Present)

Patricia Era Bath is an American ophthalmologist, inventor and academic. She has broken ground for women and African Americans in a number of areas. Prior to Bath, no woman had served on the staff of the Jules Stein Eye Institute, headed a post-graduate training program in ophthalmology or been elected to the honorary staff of the UCLA Medical Center (an honor bestowed on her after her retirement). Before Bath, no black person had served as a resident in ophthalmology at New York University and no black woman had ever served on staff as a surgeon at the UCLA Medical Center. Bath is the first African-American woman doctor to receive a patent for a medical purpose. Her Laserphaco Probe is used to treat cataracts. The holder of four patents, she is also the founder of the American Institute for the Prevention of Blindness in Washington, D.C.

Inspired by Albert Schweizer for his work in medicine, Bath applied for and won a National Science Foundation Scholarship while attending Charles Evans Hughes High School; this led her to a research project at Yeshiva University and Harlem Hospital Center on cancer that piqued her interest in medicine. In 1960, still a teenager, Bath won the "Merit Award" of Mademoiselle magazine for her contribution to the project.

After graduating high school early, Bath received her Bachelor of Arts in chemistry from New York's Hunter College in 1964. She relocated to Washington, D.C. to attend Howard University College of Medicine, from which she received her doctoral degree in 1968. During her time at Howard, she was president of the Student National Medical Association and received fellowships from the National Institutes of Health and the National Institute of Mental Health.

Bath interned at Harlem Hospital Center, subsequently serving as a fellow at Columbia University. During this period, from 1968 to 1970, Bath became aware that the practice of eye care was uneven among racial minorities and poor populations, with much higher incidence of blindness among her black and poor patients. She determined that, as a physician, she would help address this issue. She persuaded her professors from Columbia to operate on blind patients at Harlem Hospital Center, which had not previously offered eye surgery, at no cost. Bath pioneered the worldwide discipline of "community ophthalmology", a volunteer-based outreach to bring necessary eye care to underserved populations.

She served her residency in ophthalmology at New York University from 1970 to 1973, the first African American to do so in her field.

After completing her education, Bath served briefly as an assistant professor at Jules Stein Eye Institute at UCLA and Charles R. Drew University of Medicine and Science before becoming the first woman on faculty at the Eye Institute. In 1978, Bath co-founded the American Institute for the Prevention of Blindness, for which she served as president. In 1983, she became the head of a residency in her field at Charles R. Drew, the first woman ever to head such a department. In 1993, she retired from UCLA, which subsequently elected her the first woman on its honorary staff. She served as a professor of Ophthalmology at Howard University's School of Medicine and as a professor of Telemedicine and Ophthalmology at St. Georges University. She was among the co-founders of the King-Drew Medical Center ophthalmology training program.

Bath has lectured internationally and authored over 100 papers.

Bath holds four patents in the United States. In 1981, she conceived of the Laserphaco Probe, a medical device that improves on the use of lasers to remove cataracts, and "for ablating and removing cataract lenses". The device was completed in 1986 after Bath conducted research on lasers in Berlin and patented in 1988, making her the first African-American female doctor to receive a patent for a medical purpose. The device — which quickly and nearly painlessly dissolves the cataract with a laser, irrigates and cleans the eye and permits the easy insertion of a new lens — is used internationally to treat the disease. Bath has continued to improve the device and has successfully restored vision to people who have been unable to see for decades.

Three of Bath's four patents relate to the Laserphaco Probe. In 2000, she was granted a patent for a method she devised for using ultrasound technology to treat cataracts. Bath has been honored by two of her universities. Hunter College placed her in its "hall of fame" in 1988 and Howard University declared her a "Howard University Pioneer in Academic Medicine" in 1993.

Alice Augusta Ball (July 24, 1892 – December 31, 1916)

Alice Ball was an African American chemist who developed an injectable oil extract that was the most effective treatment of leprosy until the 1940s. She was also the first woman and first African American to graduate from the University of Hawaii with a master's degree.

 Ball attended Seattle High School and received top grades in the sciences. She graduated from Seattle High School in 1910 and entered the University of Washington to study chemistry. During her four years there, she earned bachelor degrees in both pharmaceutical chemistry and pharmacy. She also, with her pharmacy instructor, published a 10-page article in the prestigious Journal of the American Chemical Society titled "Benzoylations in Ether Solution." Following her graduation, Ball was offered scholarships to attend the University of California Berkeley and the University of Hawaii. Ball decided to move back to Hawaii to pursue a master's degree in chemistry. In 1915, she became the first woman and first African American to graduate with a master's degree from the University of Hawaii.

In her postgraduate research career at the University of Hawaii, Ball investigated the chemical makeup and active principle of Piper methysticum (kava) for her master's thesis. While working on her thesis, Ball was asked by Dr. Harry T. Hollmann, an assistant surgeon at Kalihi Hospital in Hawaii, to help him develop a method to isolate the active chemical compounds in chaulmoogra oil. Chaulmoogra oil had previously been used in the treatment of Hansen's disease (leprosy) with mixed results. Most patients with Hansen's disease were hesitant to take the oil over the long term because it tasted bitter and tended to cause an upset stomach. Ball developed a process to isolate the ethyl esters of the fatty acids in the chaulmoogra oil so that they could be injected, but died before she could publish her results. Another chemist at the University of Hawaii, Arthur L. Dean, continued her work and began producing large quantities of the injectable chaulmoogra extract. In 1918, a Hawaii physician reported in the Journal of the American Medical Association that a total of 78 patients were released from Kalihi Hospital by the board of health examiners after treatment with injections. The isolated ethyl ester remained the preferred treatment for Hansen's disease until sulfone drugs were developed in the 1940s.

Alice Augusta Ball died on December 31, 1916, at the age of 24. She had become ill during her research and returned to Seattle for treatment a few months before her death. A 1917 newspaper article from the Pacific Commercial Advertiser suggested that the cause may have been chlorine poisoning that occurred while teaching. However, the cause of her death is unknown as her original death certificate was altered, giving the cause of death as tuberculosis.

Although her research career was short, Ball introduced a new treatment of Hansen's disease which continued to be used until the 1940s. The University of Hawaii did not recognize her work for nearly ninety years. In 2000, the university finally honored Ball by dedicating a plaque to her on the school's lone chaulmoogra tree behind Bachman Hall. On the same day, the former Lieutenant Governor of Hawaii, Mazie Hirono, declared February 29 "Alice Ball Day" which is now celebrated every four years. More recently, Ball was honored by the University of Hawaii Board of Regents with a Medal of Distinction in 2007.

Ruth Handler (November 4, 1916 – April 27, 2002)

Perhaps one of the most famous toys in American history, the Barbie doll is a staple in the toy chests of little girls everywhere. Along with co-founding the renowned toy company Mattel, woman inventor Ruth Handler also designed the doll that would become an American cultural icon.

While watching her daughter play with paper dolls, Ruth Handler noticed that she and her friends used the dolls to act out the future rather than the present. So, she set out to invent a grown-up, three-dimensional doll that girls could use to act out their dreams. This, of course, included the presence of breasts (and what many would later call "unrealistic body proportions"). The female inventor named her new Barbie doll invention after the nickname of her daughter Barbara. Later on, a male counterpart doll would be named after her son: Ken.

After premiering at the Toy Fair in 1959, Barbie became an instant sensation. The success of the doll propelled Mattel to become a publicly owned company that soon made Fortune's list of the 500 largest U.S. industrial companies. Handler served as the company's president for several of its most successful years. Along with being an inventor and businesswoman, Ruth Handler is also a breast cancer survivor – an experience she used to start another company, Nearly Me, which manufactured realistic-looking breast prostheses.

To this day, the Barbie doll invention remains one of Mattel's best-selling products.

Dr. Temple Grandin (August 29, 1947 - Present)

The thing that usually amazes people most about prolific woman inventor Dr. Temple Grandin is not all the great strides she has made to improve animal-handling devices, nor the fact that she earned a Ph.D in animal science and became a world-renowned teacher and speaker. Instead, what usually amazes people most about Dr. Temple Grandin is that she accomplished all this while living with autism.

With guidance and mentoring, Grandin, who didn't speak until she was nearly four years old, learned to use aspects of her autism to fuel her work as an inventor. The social stigmas attached to her diagnosis also may have helped inform her belief that animals should not be mistreated or subjected to a lower quality of life. To put her beliefs into practice, Dr. Temple Grandin designed a number of inventions that use behavioral principles rather than excess force to control animals.

Dr. Grandin's restraint systems keep animals calm and prevent them from getting hurt, and her center-track restraint system is currently used to handle nearly half of all the cattle in North America. She also has designed livestock handling facilities around the world (everywhere from the U.S. and Canada to Europe and New Zealand), and developed an objective scoring system for assessing the handling of cattle and pigs at meat plants.

To help others with Autism created the "hug box", a device to calm those on the autism spectrum. The subject of an award-winning, 2010 biographical film, Temple Grandin, she also was listed in the Time 100 list of the one hundred most influential people in the world in the "Heroes" category

Along with being an inventor and animal-handling expert, Dr. Grandin is a prominent author and expert on the subject of autism. Strongly believing the characteristics of the condition can be controlled and modified, she has been featured on major television programs, such as "Today," "48 Hours" and "20/20," and written about in publications like People magazine, Forbes and The New York Times.

Bette Nesmith Graham (March 23, 1924 – May 12, 1980)

As electric typewriters came into widespread use after World War II, Bette Nesmith Graham and countless other secretaries let out a collective groan. The new machines did make typing easier, but their carbon-film ribbons made it impossible to correct mistakes neatly with a pencil eraser. As a result of this predicament, Graham ended up inventing one of the most widely used office products of the 20th century.

Born in 1924 in Dallas, Texas, Bette Graham dropped out of high school at the age of seventeen and went to secretarial school. By 1951, she had worked her way up to the position of executive secretary for W.W. Overton, the Chairman of the Board of the Texas Bank and Trust. It was at this time that Graham and her colleagues at the bank began experiencing trouble with the new IBM electric typewriters. Tired of having to retype entire pages because of one small error, Graham determined to find a more efficient alternative. Little did she know her frustration would lead to her becoming one of the most famous women inventors of the 20th century.

The impetus for Graham's breakthrough came as she observed painters decorating the bank windows for the holidays. Rather than remove their mistakes entirely, the painters simply covered any imperfections with an additional layer. The quick-thinking Graham mimicked their technique by using a white, water-based tempera paint to cover her typing errors.

When the other secretaries realized how well the invention worked, they flooded Graham with requests for their own supplies. The now-famous woman inventor sold her first batch of "Mistake Out" in 1956, and soon she was working full-time to produce and bottle it from her North Dallas home. Her son Michael – who would later achieve fame as a member of the pop group The Monkees – and his friends helped to fill the growing number of orders for Mistake Out.

Graham continued experimenting with the makeup of the substance until she achieved the perfect combination of paint and several other chemicals. The refined product was renamed "Liquid Paper" in 1958 and, amid soaring demand, Graham applied for a patent and a trademark that same year.

Graham's Liquid Paper Company experienced tremendous growth over the next decade. By 1967, the company had its own corporate headquarters and automated production plant, and sales were in excess of one million units per year. In 1975, Graham moved operations into a 35,000-sq. ft. international Liquid Paper headquarters building in Dallas.

From the start, Graham ran her company with a unique combination of spirituality, egalitarianism, and pragmatism. Raised a Methodist, Graham converted to Christian Science in 1942 and this faith inspired the development of her corporate "Statement of Policy." Part code of ethics, part business philosophy, it covered everything from her belief in a "Supreme Being" to a focus on decentralized decision making and an emphasis on product quality over profit motive. She also believed that women could bring a more nurturing and humanistic quality to the male world of business, and did so herself by including a greenbelt with a fish pond, an employee library, and a childcare center in her new company headquarters in 1975.

She sold the company to Gillette Corporation four years later, just six months before her death in 1980.

Sally Fox (December 30th, 1955 - Present)

"I never really planned to be an inventor, but my attitude toward life has always been inventive." 

–Sally Fox

In the modern world, there is an unfortunate tendency to value profit over intellect. People may know a practice is harmful, but continue to do it anyway because it produces an in-demand product. Fortunately, there are inventors who work persistently to develop more responsible solutions. Sally Fox is one such individual.

Prior to Fox's invention of Foxfibre cotton, naturally colored cotton could only be spun by hand – which was such a long and laborious process that businesses instead chose to take white cotton, bleach it, dye it and spin it on a machine. This produced the colored fabrics people wanted, but also created a lot of pollution through the bleaching and dying processes. Sadly, there weren't really any viable alternatives available – that is, until Sally Fox came along in the late 1980s and revolutionized the industry.

While working as a pollinator for a cotton breeder looking to develop more pest-resistant plants, Fox began breeding brown and green cotton, picking out the best seeds that produced the longest fibers and replanting them year after year. Eventually, she created two colored cottons that could be spun on a machine, and she purchased a small lot of land to grow them. Sally even received Plant Variety Protection Certificates (the plant equivalent of patents) for the new cottons.

By the early 90s, Sally Fox had a $10-million-dollar business that produced naturally colored cotton for major companies like Levi's, Espirit, Land's End and L.L. Bean. It was the best of both worlds – a more environmentally friendly product that was also turning a profit. After globalization forced most of the spinning mills to South America and Southeast Asia, Fox's business took a hit, but she continues to make new naturally colored cottons to this day. Each new color takes about 10 years to produce – but, for Sally Fox, the patience is worth the payoff.

Mary Anderson (1866–1953)

Mary Anderson was born in Greene County, Alabama, at the start of Reconstruction in 1866. In 1889 she moved with her widowed mother and sister to the booming town of Birmingham, Alabama. She built the Fairmont Apartments on Highland Avenue soon after settling in. By 1893, Mary Anderson had moved west to Fresno, California where until 1898 she operated a cattle ranch and vineyard.

In a visit to New York City in the winter of 1903, in a trolley car on a frosty day, she observed that the motorman drove with the front window open because of difficulty keeping the windshield clear of falling sleet. When she returned to Alabama she hired a designer for a hand-operated device to keep a windshield clear and had a local company produce a working model. She applied for, and in 1903 was granted, a 17-year patent for a windshield wiper. Her device consisted of a lever inside the vehicle that controlled a rubber blade on the outside of the windshield. The lever could be operated to cause the spring-loaded arm to move back and forth across the windshield. A counterweight was used to ensure contact between the wiper and the window. Similar devices had been made earlier, but Anderson's was the first to be effective.

In 1905 Anderson tried to sell the rights to her invention through a noted Canadian firm, but they rejected her application saying "we do not consider it to be of such commercial value as would warrant our undertaking its sale." After the patent expired in 1920 and the automobile manufacturing business grew exponentially, windshield wipers using Anderson's basic design became standard equipment. In 1922, Cadillac became the first car manufacturer to adopt them as standard equipment.

Barbara Askins (1939 - Present)

Barbara S. Askins is an American chemist. She is best known for her invention of a method to enhance underexposed photographic negatives. This development was used extensively by NASA and the medical industry, and it earned Askins the title of National Inventor of the Year in 1978.  She was the first individual woman to earn this honor.

Barbara Askins (née Scott) was born in Belfast, Tennessee, in 1939. Originally a teacher, she returned to school to pursue a science career after having had a son and daughter. Askins earned Bachelor of Science and Master of Science degrees from the University of Alabama in Huntsville.

Askins is a physical chemist who worked for NASA's Marshall Space Flight Center and is best known for her pioneering invention of a process in which "images on developed photographic emulsions can be significantly intensified by making the image silver radioactive and exposing a second emulsion to this radiation." The resulting print, known as an autoradiograph, reproduces the image with significant increases in density and contrast. Her groundbreaking method enhanced underexposed emulsions and increased the limits of photographic detection. In short, it made visible the invisible in photos that would otherwise have been useless. This was very useful for a number of applications, including the coaxing of data from underexposed space images—such as those peering deep into space as well as those highlighting the geology of other bodies in our solar system.

Askins' invention also led to significant advances in the field of medical technology. In particular, Askins' method prompted improvements in the development of X-ray images. Medical images that were 96 percent underexposed suddenly become readable; this meant that doctors could dramatically decrease the amount of X-ray radiation they gave to patients when running routine or emergency tests. Askins' process was also later used in the restoration of old photographs. Askins patented her invention in 1978 (U.S. patent No. 4,101,780), and NASA employed it extensively for its research and development work.

Askins is a member of the American Chemical Society, the Sigma Xi honorary research Society, the American Association for the Advancement of Science, and the World Future Society.

Patricia Billings (1926 - Present)

Imagine a building material that is indestructible, fire-proof and non-toxic. Sounds like something you'd find in a work of science fiction, but actually it's a very-real invention called Geobond®, designed by female inventor Patricia Billings.

Patty Billings, a sculptor, initially sought to create a cement additive to prevent her sculptures from shattering in the 1970s. After years of experimenting, she finally achieved her goal of making an indestructible plaster. Soon after, she discovered the material was also amazingly resistant to heat(it could resist heat up to temperatures over 6,500 degrees) – which opened the door to a larger number of applications. Because the Geobond® invention is non-toxic as well as indestructible and fire-proof, it is the world's first workable replacement for asbestos after asbestos was found to cause cancer..

While Patricia Billings has two patents on her work, she continues to keep the exact recipe of Geobond® a secret. The inventor and great-grandmother hopes to see her invention used to revolutionize the construction industry, and she even turned down millions of dollars from a company she thought would try to bury her new technology.

Marion Donovan (October 15, 1917 - November 4, 1998)

Born in Fort Wayne, Indiana in 1917, Marion Donovan was instilled with an inventive spirit at a young age. She spent the greater part of her childhood hanging around the manufacturing plant run by her father and uncle, two men who combined to invent, among other things, an industrial lathe for grinding automobile gears and gun barrels.

Years later, as a post-World War II housewife and mother of two in Connecticut, Donovan would make good use of the ingenuity that she had observed in her youth. Frustrated by the thankless, repetitive task of changing her youngest child's soiled cloth diapers, bed sheets and clothing, she decided to craft a diaper cover to keep her baby – and the surrounding area – dry. Donovan sat down at her sewing machine with a shower curtain and, after several attempts, she completed a waterproof diaper cover.

Unlike the rubber baby pants that were already on the market, Donovan's design did not cause diaper rash and did not pinch the child's skin. The soon-to-be famous female inventor subsequently perfected her invention, adding snap fasteners in place of the dangerous safety pins that were commonly used. Donovan named her diaper cover the "Boater" and explained that "at the time I thought that it looked like a boat."

When no manufacturers would even consider her invention, Donovan struck out on her own, and the Boater was an unqualified success from the day it debuted at Saks Fifth Avenue in 1949. Donovan received a patent in 1951 and promptly sold the rights to Keko Corporation.

Her next project was a fully disposable diaper, for which she had to fashion a special type of paper that was not only strong and absorbent, but also conveyed water away from the baby's skin. Donovan took her finished product to every large manufacturer in the country, but once again she found no takers. Incredulously, everyone she talked to told her that the idea was superfluous and impractical. It was not until nearly a decade later, in 1961, that Victor Mills drew upon Donovan's vision to create Pampers®.

In keeping with her innovative heritage, this "mother of invention" explored numerous ventures that were completely unrelated to her diaper improvements. She earned a total of 20 patents in her lifetime and also received an Architecture degree from Yale University in 1958. Although Donovan's extraordinary life may go largely unnoticed by the public, this famous woman inventor deserves the undying gratitude of new parents around the globe.

Eva Crane (June 12, 1912 – September 6, 2007)

Eva Crane was a researcher and author on the subjects of bees and beekeeping. Trained as a quantum mathematician, she changed her field of interest to bees, and spent decades researching bees, traveling to more than 60 countries, often under primitive conditions. The New York Times reported that "Dr. Crane wrote some of the most important books on bees and apiculture" and noted "Her older sister, Elsie Widdowson, who never retired either, helped revolutionize the field of nutrition, showing similar energy chasing seals on ice floes to study their eating habits."

Born as Ethel Eva Widdowson in London she earned a Ph.D in 1941 in nuclear physics. She became a lecturer in Physics at Sheffield University. She married James Crane, a stockbroker serving in the Royal Navy Volunteer Reserve, in 1942. Her husband died in 1978.

Her interest in bees began when she and her husband received a beehive as a wedding present; the giver had hoped that it would help supplement their wartime sugar ration.

Crane wrote over 180 papers, articles, and books, many when she was in her 70s and 80s. Honey: A Comprehensive Survey (1975), in which she contributed several important chapters, and edited, came about because she told the publisher (Heinemann Press) that a book on the subject was sorely needed. Although now out of print, it remains the most significant review on the subject ever written. A Book of Honey (1980) and The Archaeology of Beekeeping (1983) reflected her strong interests in nutrition and the ancient past of beekeeping.

Her writing culminated in two mighty, encyclopaedic tomes, Bees and Beekeeping: science, practice and world resources (1990; at 614 pages) and The World History of Beekeeping and Honey Hunting (1999; 682 pages). These distilled a lifetime's knowledge and experience and are regarded as seminal textbooks throughout the beekeeping world.

Elsie Widdowson (October 21, 1906 – June 14, 2000)

Elsie Widdowson, was a British dietitian. She and Dr Robert McCance were responsible for overseeing the government-mandated addition of vitamins to food and war-time rationing in Britain during World War II.

Widdowson was born in Wallington, Surrey. Her father was a grocer's assistant. Her younger sister Eva Crane trained as a nuclear physicist but became a world renowned authority on bees.

She lived in Dulwich and attended Sydenham County Grammar School for Girls. She studied chemistry at Imperial College, London and graduated with a BSc in 1928, becoming one of the first women graduates of Imperial College. She did postgraduate work at the Department of Plant Physiology at Imperial College, receiving a PhD in chemistry in 1931 for her thesis on the carbohydrate content of apples. She did further research with Professor Charles Dodds at the Courtauld Institute of Biochemistry at Middlesex Hospital, on the metabolism of the kidneys, and also received a doctorate from the Courtauld Institute.

Dodds suggested that Widdowson should consider specialising in dietetics, and she started a postgraduate diploma at King's College, London. Widdowson met Robert McCance in the kitchens at St Bartholomew's Hospital in 1933, where she was studying industrial cooking techniques as part of her diploma on dietetics. McCance was a junior doctor researching the chemical effects of cooking as part of his clinical research on the treatment of diabetes. Widdowson pointed out an error in McCance's analysis of the fructose content of fruit, and they both realised that there were significant errors in the standard nutritional tables. They became scientific partners and worked together for the next 60 years, until McCance died in 1993.

McCance became a Reader in Medicine at Cambridge University in 1938, and Widdowson joined his team at the Department of Experimental Medicine in Cambridge. They worked on the chemical composition of the human body, and on the nutritional value of different flours used to make bread. Widdowson also studied the impact of infant diet on human growth. They studied the differing effects from deficiencies of salt and of water, and produced the first tables to compare the different nutritional content of foods before and after cooking. Their work became of national importance during the Second World War. Widdowson and McCance were co-authors of The Chemical Composition of Foods, first published in 1940 by the Medical Research Council. Their book "McCance and Widdowson" became known as the dietician's bible and formed the basis for modern nutritional thinking.

Widdowson and McCance and their colleagues became their own experimental subjects, eating a starvation diet of bread, cabbage and potatoes for several months to find out if wartime rationing - with little meat, dairy or calcium intake - would affect their health. They showed that good health could be supported by a very restricted diet, with calcium supplements, and their work became the basis of the wartime austerity diet promoted by the Minister of Food Lord Woolton.

Widdowson and McCance headed the first mandated addition of vitamins and mineral to food. Their work began in the early 1940s, when calcium was added to bread. They were also responsible for formulating the war-time rationing of Britain during World War II.

Widdowson and McCance were employed by the Medical Research Council from 1946, and spent most of their working life in Cambridge. They were consulted on the rehabilitation of the victims of severe starvation in Nazi concentration camps, and visited Holland, Germany and Denmark in early 1946 to study of the impact of the poor wartime diet on the people in Nazi-occupied territories. Widdowson followed up this work in the 1950s, 1960s and 1970s by studying malnourishment in Africa. Research on animals showed that malnourishment in early life led to lifelong effects on growth and health.

Widdowson showed that a new-born human infant has 16 per cent of its weight as fat, much greater than the one or two per cent of other species. She also studied the importance of the nutritional content of infant diets, particularly trace vitamins and minerals in natural and artificial human milk. Her work led to revised standards for breast milk substitutes in the UK in the 1980s.

Widdowson became head of the Infant Nutrition Research Division at the Dunn Nutritional Laboratory in Cambridge in 1966. She formally retired in 1972, but continued academic research in the Department of Investigative Medicine at Addenbrooke's Hospital. She was president of the Nutrition Society from 1977 to 1980, president of the Neonatal Society from 1978 to 1981, and president of the British Nutrition Foundation from 1986 to 1996. She became a Fellow of Imperial College in 1994.

She became a Fellow of the Royal Society in 1976 and was appointed a CBE in 1979. She was made a member of the Order of the Companions of Honour in 1993, which is awarded for outstanding achievements in the arts, literature, music, science, politics, industry, or religion.

The British Nutrition Foundation published a book in 1993 to celebrate 60 years of her partnership with McCance, McCance & Widdowson. A Scientific Partnership of 60 Years, 1933–1993, edited by Margaret Ashwell.

Widdowson lived in Barrington near Cambridge for over 50 years. She ate a simple diet, including butter and eggs, and attributed her longevity to good genes: her father lived to 96 and her mother to 107. She died at Addenbrooke's Hospital after suffering a stroke while on holiday with her sister in Ireland. She never married.

Elsa Theresa Andersson (April 27, 1897 - January 22, 1922)

Elsa Theresa Andersson, Swedish aviation pioneer, called the chipper Scanian. She was the first Swedish woman to receive a pilot's license.

Andersson was born in St. Peter's Farm in Strövelstorpsvägen near Angelholm , Skane , Sweden, daughter of farmer Edward Andersson and his wife, Alma Svensson.

In her early youth, she became fascinated by flight and studied in the Enoch Thulin flight school at Ljungbyhed . She became the school's 101st student and the last student because the school was closed down in connection with the company's bankruptcy in 1920. On 30 June 1920 she received her pilots license and became the first Swedish woman.

She was not content with this and dreamed of going further and train as a skydiver. The only expert in the area of Sweden, Raoul Thörnblad , refused teach women the art. Andersson then traveled to Berlin in 1921 to go to Otto Heineckes parachute school. The course included two student jump and theoretical training.

Andersson made ​​her first exhibition jump October 2, 1921 outside Kristianstad and her next jump took place a week later outside Helsingborg .

Her third jump occurred before several thousand spectators at Edö outside Askersund January 22, 1922 pilot Albin Lundberg carried her up to about 650 meters, where she jumped. The parachute did not open immediately, because the cord wrapped around her arm. She tried to resolve the critical situation but failed, she struck down in a wooded mountainous area along the road to Edö and died immediately upon impact. On the site traveled Royal Swedish Aero Club is a memorial in 1926.

Elsa Andersson is buried in Strövelstorpsvägen .

Émilie du Châtelet (17 December 1706 – 10 September 1749)

Gabrielle Émilie Le Tonnelier de Breteuil, marquise du Châtelet was a French mathematician, physicist, and author during the Age of Enlightenment. Her crowning achievement is considered to be her translation and commentary on Isaac Newton's work Principia Mathematica. The translation, published posthumously in 1759, is still considered the standard French translation.

Voltaire, one of her lovers, declared in a letter to his friend King Frederick II of Prussia that du Châtelet was "a great man whose only fault was being a woman". She was also romantically linked with two other influential philosophers of the period, Pierre-Louis Moreau de Maupertius (1698-1759) and Julien Offray de La Mettrie (1709-51).

Du Châtelet's education has been the subject of much speculation, but nothing is known with certainty.

Among their acquaintances was Fontenelle, the perpetual secretary of the French Académie des Sciences. Émilie's father Louis-Nicolas, recognizing her early brilliance, arranged for Fontenelle to visit and talk about astronomy with her when she was 10 years old. Émilie's mother, Gabrielle-Anne de Froulay, was brought up in a convent, at the time the predominant educational institution available to French girls and women. While some sources believe her mother did not approve of her intelligent daughter, or of her husband's encouragement of Émilie's intellectual curiosity, there are also other indications that her mother not only approved of du Châtelet's early education, but actually encouraged her to vigorously question stated fact.

In either case, such encouragement would have been seen as unusual for parents of their time and status. When she was small, her father arranged training for her in physical activities such as fencing and riding, and as she grew older, he brought tutors to the house for her. As a result, by the age of twelve she was fluent in Latin, Italian, Greek and German; she was later to publish translations into French of Greek and Latin plays and philosophy. She received education in mathematics, literature, and science. Her mother Gabrielle-Anne was horrified at her progress and fought Louis-Nicolas at every step, once attempting to have Émilie sent to a convent.

In 1733, at the age of 26, du Châtelet resumed her mathematical studies. Initially, she was tutored in algebra and calculus by Moreau de Maupertuis, a member of the Academy of Sciences. Although mathematics was not his forte, Maupertuis had received a solid education from Johann Bernoulli, who also taught Leonhard Euler. By 1735, however, du Châtelet had turned for her mathematical training to Alexis Clairaut, a mathematical prodigy known best for Clairaut's equation and Clairaut's theorem.

Scientific Research and Publications

Criticizing Locke and the debate on thinking matter
In her writings, Emilie du Châtelet criticizes John Locke’s philosophy in an elementary respect. She emphasizes the necessity of the verification of knowledge through experience: Locke’s idea of the possibility of thinking matter is […] abstruse. Her critique on Locke originates in her Bernard de Mandeville commentary [on the Fable of the Bees]. She confronts us with her resolute statement in favor of universal principles which precondition human knowledge and action, and maintains that this kind of law is innate. […] Du Châtelet claims the necessity of a universal presupposition, because if there is no such beginning, all our knowledge is relative. In that way, Du Châtelet rejects John Locke’s aversion of innate ideas and a priori principles. She also reverses Locke’s negation of the principle of contradiction, which would constitute the basis of her methodic reflections in the Institutions. On the contrary, she affirms her arguments in favor of the necessity of a priori and universal principles. “two and two could then make as well 4 as 6” if a priori principles did not exist.

Pierre Louis Moreau de Maupertuis’ and Julien Offray de La Mettrie’s reference to Du Châtelet's deliberations on motion and free will, on thinking matter and numbers and on the way to do metaphysics indicate the importance of her reflections. She rebuts the claim to finding truth by using mathematical laws, […] and argues against Maupertuis.

Heat and light
Dissertation Sur La Nature et La Propagation du feu, 1744
In 1737, Châtelet published a paper entitled Dissertation sur la nature et la propagation du feu, based upon her research into the science of fire, that predicted what is today known as infrared radiation and the nature of light.

Institutions de Physique
Her book Institutions de Physique (“Lessons in Physics”) appeared in 1740; it was presented as a review of new ideas in science and philosophy to be studied by her thirteen-year-old son, but it incorporated and sought to reconcile complex ideas from the leading thinkers of the time.

Forces Vives
Réponse de Madame la Marquise du Chastelet, 1741
In 1741, du Châtelet published a small book entitled Réponse de Madame la Marquise du Chastelet, a la lettre que M. de Mairan. Dortous de Mairan, secretary of the Academy of Sciences, had published a set of arguments addressed to her regarding the appropriate mathematical expression for forces vives. Du Châtelet presented a spirited point by point rebuttal of de Mairan's arguments, which caused him to withdraw from the controversy.

Advocacy of kinetic energy
Although in the early 18th century the concepts of force and momentum had been long understood, the idea of energy as a transferrable currency between different systems, was still in its infancy and would not be fully resolved until well into the 19th Century. Émilie du Châtelet contributed towards this resolution when, inspired by the theories of Gottfried Leibniz, she repeated and publicized an experiment originally devised by Willem 's Gravesande in which balls were dropped from different heights into a sheet of soft clay. Each ball's kinetic energy - as indicated by the quantity of material displaced - was shown conclusively to be proportional to the square of the velocity. Earlier workers like Newton and Voltaire had all believed that "energy" (so far as they understood the concept at all) was indistinct from momentum and therefore proportional to velocity. In classical physics the correct formula is E_k = \frac12 mv^2, where E_k is the kinetic energy of an object, m its mass and v its velocity.) Some commentators have perceived this as a precursor to the c^2 multiplier in Albert Einstein's mass-energy formula, and indeed \frac12 mv^2 is the first term in the binomial expansion of the relativistic kinetic energy expression.

Translation and commentary on Newton's Principia
In 1749, the year of her death, she completed the work regarded as her outstanding achievement: her translation into French, with her commentary, of Newton’s Principia Mathematica, including her derivation of the notion of conservation of energy from its principles of mechanics. Published ten years after her death, today du Châtelet's translation of Principia Mathematica is still the standard translation of the work into French.

Other contributions

Development of financial derivatives
Much later in life, she once lost the huge sum of 84,000 francs—some of it borrowed—in one evening at the table at the court of Fontainebleau, to card cheats. To quickly raise the money to pay back her debts, she devised an ingenious financing arrangement similar to modern derivatives, whereby she paid tax collectors a fairly low sum for the right to their future earnings (they were allowed to keep a portion of the taxes they collected for the King), and promised to pay the court gamblers part of these future earnings.

Biblical scholarship
Du Châtelet wrote a critical analysis of the Bible, specifically the book of Genesis and those of the New Testament.

Discourse on happiness
Du Châtelet also wrote a monograph, Discours sur le bonheur, on the nature of happiness, both in general and specialized to women.

Translation of the Fable of the Bees, and other works
Du Châtelet translated The Fable of the Bees in a free adaptation. She also wrote works on optics, rational linguistics, and the nature of free will.

Support of women's education
In her first independent work, the preface to her translation of the Fable of the Bees, du Châtelet argues strongly for women's education, particularly a strong secondary education as was available for young men in the French collèges. By denying women a good education, she argues, society prevents women from becoming eminent in the arts and sciences.

Legacy

Although the classical mechanics of du Châtelet are not approached with the same accuracy as Einstein's concept of mass and velocity,[20] in his famous equation for the energy equivalent of matter E = mc² (where c represents the velocity of light), modern biographers and historians continue to see a neat accord with the principle E ∝ mv² first recognised by du Châtelet from over 150 years before. It should be emphasized, however, that from a physical point of view, du Châtelet's principle is a correct assessment of the kinetic energy in classical mechanics, and is the first term in an expansion of Einstein's mass–energy equivalence.

A main-belt minor planet and a crater on Venus have been named in her honor, and she is the subject of three plays: Legacy of Light by Karen Zacarías; Emilie: La Marquise Du Châtelet Defends Her Life Tonight by Lauren Gunderson and Urania: the Life of Emilie du Châtelet by Jyl Bonaguro. The opera Émilie of Kaija Saariaho is about the last moments of her life.

Du Châtelet is often represented in portraits with mathematical iconography, such as holding a pair of dividers or a page of geometrical calculations. In the early nineteenth century, a French pamphlet of celebrated women (Femmes célèbres) introduced a possibly apocryphal story of du Châtelet's childhood. According to this story, a servant fashioned a doll for her by dressing up wooden dividers as a doll; however, du Châtelet undressed the dividers and intuiting their purpose, made a circle with them.

Elsa Beata Bunge (18 April 1734–19 January 1819)

Elsa Beata Bunge (Elsa Beata Wrede) was a Swedish, botanist, writer and noble.

Elsa Beata was the daughter of statesman and noble, baron Fabian Wrede, and Katarina Charlotta Sparre. In 1761, she married the statesman Count Sven Bunge. She was an enthusiastic amateur botanist and had large greenhouses set up at her manor Beateberga; the name of the estate means "The Mountain of Beata". Bunge was connected to the Royal Swedish Academy of Sciences and corresponded with Carl von Linné. She became well known as a botanist and wrote the botanical work Om vinrankors beskaffenhet efter sjelfva naturens anvisningar (English: "About the nature of vine grapes by direction from nature itself") with tables (1806), the work for which she was recognised as a botanist.

As a person, Countess Bunge aroused attention because of her way of dressing as a man, with the exception of a skirt. A lot of stories and anectodets are told about her. During the reign of Gustav III (1771–1792), the monarch noticed a peculiarly dressed woman in the Royal Swedish Opera and enquired who she was. Bunge replied : "Tell His Majesty that I am the daughter of statesman Fabian Wrede and married to statesman Sven Bunge."

She died on Beateberga manor in Röö Parish in 1819.

Margaret Eliza Maltby (10 December 1860 – 3 May 1944)

Margaret Eliza Maltby was an American physicist notable for measurement of high electrolytic resistances and conductivity of very dilute solutions. She was born in Bristolville, Ohio, and died in New York City.

Most of her significant research occurred before she began teaching at Barnard College, a women's college founded in 1889, where her involvement in administration left her little time for research. Maltby was a mentor to her students, vigorously extending efforts to support their professional advancement. During her 31 years of teaching at Barnard, and the nearly 20 years that she was chair of the physics department, Maltby took a great interest in her students' learning, even introducing physics courses for non-physicists, including probably the first course in the physics of music.

There are many examples of her efforts to support the professional advancement of female physicists. As chair of the American Association of University Women (AAUW) Committee on Fellowships, Maltby administered funds that supported women actively engaged in physics research during the early part of their careers. Since women were not eligible for many research fellowships because of their gender, the AAUW Fellowships were critical for maintaining a cadre of women physicists. Maltby's enormous effort contributed to the Fellowships' preservation.

Despite the college's Dean's Rule that stated, "the College cannot afford to have women on the staff to whom the college work is secondary; the College is not willing to stamp with approval a woman to whom self-elected home duties can be secondary," Maltby supported women's efforts to do both. As chair of the Physics Department, she vigorously opposed the forced resignation of Harriet Brooks when she planned to marry.

Physicist and History of Science interviewer Katharine Sopka wrote that her students greatly admired her. One wrote her that, "Professor Maltby was my mentor--a gracious lady--a friend and a counselor. Her most memorable advice to me was not to forgo marriage for a career--which advice I followed and lived happily ever after." Maltby, never married, although she adopted the orphaned son of a close friend in 1901.

The first edition of American Men of Science, published in 1906, recognized her name with star to note her as one of the country's top scientists.

Education

A.B. Oberlin College 1882
A.M. Oberlin College 1891
B.S. Massachusetts Institute of Technology 1891
Ph.D. Göttingen University 1895 under Friedrich Kohlrausch.

In 1887, Maltby enrolled as a "special student" at MIT because the institution did not accept female students. She was the first woman to earn a B.S. degree at MIT in 1891. She was the first American woman allowed to take a degree at University of Göttingen in 1895. She was also the first woman to receive a PhD from Göttingen University; in fact, she was the first woman to obtain a physics PhD from any German university. She completed a year of postdoctoral work at Göttingen.

Career

1889-93 Chair, Physics Department, Wellesley College
1897-98 Instructor, Lake Erie College
1898-99 Research Assistant, Physikalisch-Technische Reichsanstalt, Charlottenburg, Germany
1900-03 Instructor, Chemistry Department, Barnard College, Columbia University
1903-10 Adjunct Professor, Physics Department, Barnard College
1910-13 Assistant Professor, Barnard College
1913-31 Associate Professor and Chair, Physics Department, Barnard College

Invited back to Germany in 1898, Maltby worked under Friedrich Kohlrausch and helped set the methodology in the field of conductivity.

Eva Ekeblad (10 July 1724 – 15 May 1786)

Eva Ekeblad, née Eva De la Gardie, was a Swedish agronomist, scientist, Salonist and noble (Countess). Her most known discovery was to make flour and alcohol out of potatoes (1746). She was the first female member of the Royal Swedish Academy of Sciences (1748).

Life

Eva De la Gardie was born to statesman count Magnus Julius De la Gardie (1668–1741) and the amateur politician and salonist Hedvig Catharina Lilje.

Eva was at the age of 16 (1740) married to the statesman count Claes Claesson Ekeblad, and became the mother of seven children (one son and six daughters). The couple had a residence in Stockholm and an estate in Västergötland and belonged to the very highest circles of the Swedish nobility. Eva Ekeblad was renowned for her charity to the poor.

Her spouse was often absent, and Eva was responsible for the management for the estates and supervised the bailiffs and the country-assemblys of Mariedal and Stola Manor. In Stockholm, she hosted a culturel salon and was described as "one of few aristocratic ladies whose honour was considered untainted". The first concert performings of the mass music of Johan Helmich Roman were performed in her salon at the Ekeblad palace.

Scientific Activity

Ekeblad discovered how to make flour and alcohol out of potatoes (1746). She thereby made potatoes, a plant introduced in Sweden in 1658 but until then only cultivated in the greenhouses of the aristocracy, a part of the basic food supply. This greatly improved eating habits and reduced the hunger epidemics. Previously, alcohol had been made by wheat, rye and barley, but now, more of that could be saved to make bread instead.

She also discovered a method of bleaching cotton textile and yarn with soap (1751), and of replacing the dangerous ingredients in the cosmetics of the time by making powder from potatoes (1752). She was said to have advertised the use of potatoes by using the flowers of the plant as hair ornaments.

Eva wrote to the Royal Swedish Academy of Sciences about her first discovery in 1746. In 1748, she became the first woman elected to the Academy, although she never took part in any of the Academy's meeting. After 1751, the Academy came to refer to her as an honorary rather than a full member, as the statutes confined membership to men.

Maria Christina Bruhn (1732–1802)

Maria Christina Bruhn was a Swedish inventor, likely to be the first patented female inventor of her country.

Bruhn was the eldest of three daughters of the book printer Johan Bruhn (d. 1742). She took over a tapestry- and wallpaper manufactury after the death of her widowed mother Inga Christina in 1751. In 1771, the Royal Swedish Academy of Sciences offered a reward for anyone who would be able to produce a suitable package for gunpowder for the army. During her work manufacturing paint and preparing paper, she had been inspired to the idea which she presented to the academy March 2, 1774. In a letter form 1783, she explained that she often experimented during her work. The men of the Academy expressed deep skepticism against the invention of a woman, and it took twelve years of testing, during which she had to fight among others the attempts of Anrep, General of the Artillery, to take credit for her invention, before the ministry of war approved it, recognized her as its inventor and gave her the reward in 1786. Her invention was long used within the Swedish army.

Nellie Bly (May 5, 1864 – January 27, 1922)

Nellie Bly was the pen name of American journalist Elizabeth Jane Cochrane. She was a ground-breaking reporter known for a record-breaking trip around the world in 72 days, in emulation of Jules Verne's fictional character Phileas Fogg, and an exposé in which she faked insanity to study a mental institution from within. She was a pioneer in her field, and launched a new kind of investigative journalism. In addition to her writing, she was also an industrialist and charity worker.

She was born Elizabeth Jane Cochran in "Cochran Mills", today part of the Pittsburgh suburb of Burrell Township, Armstrong County, Pennsylvania. Her father, Michael Cochran, was a modest laborer and mill worker who married Mary Jane. Cochran taught his young children a cogent lesson about the virtues of hard work and determination, buying the local mill and most of the land surrounding his family farmhouse. As a young girl Elizabeth was often called "Pinky" because she so frequently wore the color. As she became a teenager she wanted to portray herself as more sophisticated, and so dropped the nickname and changed her surname to Cochrane. She attended boarding school for one term, but was forced to drop out due to lack of funds.

In 1880, Cochrane and her family moved to Pittsburgh. An aggressively misogynistic column titled "What Girls Are Good For" in the Pittsburgh Dispatch prompted her to write a fiery rebuttal to the editor under the pseudonym "Lonely Orphan Girl". The editor George Madden was impressed with her passion and ran an advertisement asking the author to identify herself. When Cochrane introduced herself to the editor, he offered her the opportunity to write a piece for the newspaper, again under the pseudonym "Lonely Orphan Girl". After her first article for the Dispatch, titled "The Girl Puzzle", Madden was impressed again and offered her a full-time job. Female newspaper writers at that time customarily used pen names, and for Cochrane the editor chose "Nellie Bly", adopted from the title character in the popular song "Nelly Bly" by Stephen Foster. She originally intended for her pseudonym to be "Nelly Bly," but her editor wrote "Nellie" by mistake, and the error stuck.

As a writer, Bly focused her early work for the Dispatch on the plight of working women, writing a series of investigative articles on female factory workers. But editorial pressure pushed her to the so-called "women's pages" to cover fashion, society, and gardening, the usual role for female journalists of the day. Dissatisfied with these duties, she took the initiative and traveled to Mexico to serve as a foreign correspondent. Still only 21, she spent nearly half a year reporting the lives and customs of the Mexican people; her dispatches were later published in book form as Six Months in Mexico. In one report, she protested the imprisonment of a local journalist for criticizing the Mexican government, then a dictatorship under Porfirio Díaz. When Mexican authorities learned of Bly's report, they threatened her with arrest, prompting her to leave the country. Safely home, she denounced Díaz as a tyrannical czar suppressing the Mexican people and controlling the press.

Asylum exposé

Burdened again with theater and arts reporting, Bly left the Pittsburgh Dispatch in 1887 for New York City. Penniless after four months, she talked her way into the offices of Joseph Pulitzer's newspaper, the New York World, and took an undercover assignment for which she agreed to feign insanity to investigate reports of brutality and neglect at the Women's Lunatic Asylum on Blackwell's Island.

After a night of practicing deranged expressions in front of a mirror, she checked into a working-class boardinghouse. She refused to go to bed, telling the boarders that she was afraid of them and that they looked crazy. They soon decided that she was crazy, and the next morning summoned the police. Taken to a courtroom, she pretended to have amnesia. The judge concluded she had been drugged.

She was then examined by several doctors, who all declared her to be insane. "Positively demented," said one, "I consider it a hopeless case. She needs to be put where someone will take care of her." The head of the insane pavilion at Bellevue Hospital pronounced her "undoubtedly insane". The case of the "pretty crazy girl" attracted media attention: "Who Is This Insane Girl?" asked the New York Sun. The New York Times wrote of the "mysterious waif" with the "wild, hunted look in her eyes", and her desperate cry: "I can't remember I can't remember."

Committed to the asylum, Bly experienced its conditions firsthand. The food consisted of gruel broth, spoiled beef, bread that was little more than dried dough, and dirty undrinkable water. The dangerous patients were tied together with ropes. The patients were made to sit for much of each day on hard benches with scant protection from the cold. Waste was all around the eating places. Rats crawled all around the hospital. The bathwater was frigid, and buckets of it were poured over their heads. The nurses were obnoxious and abusive, telling the patients to shut up, and beating them if they did not. Speaking with her fellow patients, Bly was convinced that some were as sane as she was. On the effect of her experiences, she wrote:

"What, excepting torture, would produce insanity quicker than this treatment? Here is a class of women sent to be cured. I would like the expert physicians who are condemning me for my action, which has proven their ability, to take a perfectly sane and healthy woman, shut her up and make her sit from 6 a.m. until 8 p.m. on straight-back benches, do not allow her to talk or move during these hours, give her no reading and let her know nothing of the world or its doings, give her bad food and harsh treatment, and see how long it will take to make her insane. Two months would make her a mental and physical wreck.

…My teeth chattered and my limbs were …numb with cold. Suddenly, I got three buckets of ice-cold water…one in my eyes, nose and mouth."

After ten days, Bly was released from the asylum at The World's behest. Her report, later published in book form as Ten Days in a Mad-House, caused a sensation and brought her lasting fame. While embarrassed physicians and staff fumbled to explain how so many professionals had been fooled, a grand jury launched its own investigation into conditions at the asylum, inviting Bly to assist. The jury's report recommended the changes she had proposed, and its call for increased funds for care of the insane prompted an $850,000 increase in the budget of the Department of Public Charities and Corrections. They also made sure that future examinations were more thorough so that only the seriously ill actually went to the asylum.

Around the world

In 1888, Bly suggested to her editor at the New York World that she take a trip around the world, attempting to turn the fictional Around the World in Eighty Days into fact for the first time. A year later, at 9:40 a.m. on November 14, 1889, and with two days' notice,[13] she boarded the Augusta Victoria, a steamer of the Hamburg America Line, and began her 24,899-mile journey.

She brought with her the dress she was wearing, a sturdy overcoat, several changes of underwear and a small travel bag carrying her toiletry essentials. She carried most of her money (£200 in English bank notes and gold in total as well as some American currency)[15] in a bag tied around her neck.

The New York newspaper Cosmopolitan sponsored its own reporter, Elizabeth Bisland, to beat the time of both Phileas Fogg and Bly. Bisland would travel the opposite way around the world. To sustain interest in the story, the World organized a “Nellie Bly Guessing Match” in which readers were asked to estimate Bly’s arrival time to the second, with the Grand Prize consisting at first of (only) a free trip to Europe and, later on, spending money for the trip

On her travels around the world, Bly went through England, France (where she met Jules Verne in Amiens), Brindisi, the Suez Canal, Colombo (Ceylon), the Straits Settlements of Penang and Singapore, Hong Kong, and Japan. The development of efficient submarine cable networks and the electric telegraph allowed Bly to send short progress reports, though longer dispatches had to travel by regular post and were thus often delayed by several weeks.

Bly travelled using steamships and the existing railroad systems, which caused occasional setbacks, particularly on the Asian leg of her race. During these stops, she visited a leper colony in China and she bought a monkey in Singapore.

As a result of rough weather on her Pacific crossing, she arrived in San Francisco on the White Star Line ship Oceanic on January 21, two days behind schedule. However, World owner Pulitzer chartered a private train to bring her home, and she arrived back in New Jersey on January 25, 1890, at 3:51 p.m.

"Seventy-two days, six hours, eleven minutes and fourteen seconds after her Hoboken departure" Bly was back in New York. She had circumnavigated the globe almost unchaperoned. Bisland was, at the time, still crossing the Atlantic, only to arrive in New York four and a half days later. Like Bly, she had missed a connection and had to board a slow, old ship (the Bothina) in the place of a fast ship (Etruria). Bly's journey was a world record, though it was bettered a few months later by George Francis Train, who completed the journey in 67 days. By 1913, Andre Jaeger-Schmidt, Henry Frederick and John Henry Mears had improved on the record, the latter completing the journey in less than 36 days.

Later years

In 1895 Nellie Bly married millionaire manufacturer Robert Seaman, who was 40 years her senior. She retired from journalism, and became the president of the Iron Clad Manufacturing Co., which made steel containers such as milk cans and boilers. In 1904, her husband died. In the same year, Iron Clad began manufacturing the steel barrel that was the model for the 55-gallon oil drum still in widespread use in the United States. Although there have been claims that Nellie Bly invented the barrel, the inventor is believed to have been Henry Wehrhahn, who likely assigned his invention to her. (US Patents 808,327 and 808,413). Nellie Bly was, however, an inventor in her own right, receiving US patent 697,553 for a novel milk can and US patent 703,711 for a stacking garbage can, both under her married name of Elizabeth Cochrane Seaman. For a time she was one of the leading female industrialists in the United States, but embezzlement by employees led her into bankruptcy. Back in reporting, she wrote stories on Europe's Eastern Front during World War I and notably covered the Woman Suffrage Parade of 1913. Her headline for the Parade story was “Suffragists Are Men's Superiors” but she also "with uncanny prescience" predicted in the story that it would be 1920 before women would win the vote.

In 1916 Nellie was given a baby boy whose mother requested Bly to look after him and see that he become adopted. The child was illegitimate and difficult to place since he was half-Japanese. He spent the next six years in an orphanage run by the Church For All Nations in Manhattan.

As Bly became ill towards the end of her life she requested that her niece, Beatrice Brown, look after the boy and several other babies in whom she had become interested. Her interest in orphanages may have been part of her ongoing efforts to improve the social organizations of the day.

She died of pneumonia at St. Mark's Hospital in New York City in 1922, at age 57. She was interred in a modest grave at Woodlawn Cemetery in the Bronx.